In this study, we assessed Intensive Care Unit (ICU) admissions of 16,954 younger women and men < 52 years over a period of 12 years. We observed that ICU admissions for acute myocardial infarction decreased more in women than in men while ICU mortality for AMI significantly increased in women, but remained unchanged in men. In stroke patients, ICU admission rates increased between 3.6 and 4.1% per year in both sexes, while ICU mortality tended to decrease only in women, but remained essentially unaltered in men. Interventions aimed at restoring tissue perfusion were more often performed in men with acute myocardial infarction, while no sex difference was noted in neurovascular interventions. Our data show that sex and gender disparities in disease management and outcomes persist in the era of modern interventional neurology and cardiology with opposite trends observed in younger stroke and acute myocardial infarction patients admitted to intensive care.